Kubo S, Kinouchi K, Taniguchi A, Fukumitsu K, Kitamura S
Department of Anesthesiology, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi 594-1101.
Masui. 2001 Apr;50(4):371-7.
We compared recovery characteristics of propofol anesthesia with those of sevoflurane anesthesia in pediatric outpatients. One hundred and four children, 3 months to 6 years of age, ASA physical status 1 or 2, were randomly assigned to following four groups; sevoflurane (group S), propofol (group P), sevoflurane with premedication (group MS), or propofol with premedication (group MP). Midazolam 0.5 mg.kg-1 and famotidine 1 mg.kg-1 were administered orally 30 min before the induction in the MS and MP group. Recovery from anesthesia, agitation, and postoperative pain were evaluated. The time intervals from the end of surgery to extubation and to discharge from the hospital were recorded. The incidence of vomiting and use of analgesic drugs were also checked. The emergence from anesthesia was slower with propofol anesthesia than with sevoflurane anesthesia, but the time to discharge from the hospital was not significantly different among the four groups. Incidence of agitation was higher in S group compared with P group, but there were no differences between MS and MP. Postoperative pain was similar among the four groups. There were no differences in the incidence of vomiting. Propofol anesthesia provided slower emergence and less agitation compared with sevoflurane anesthesia.
我们比较了小儿门诊患者丙泊酚麻醉与七氟醚麻醉的恢复特征。104名3个月至6岁、ASA身体状况为1或2的儿童被随机分为以下四组：七氟醚组（S组）、丙泊酚组（P组）、术前用药的七氟醚组（MS组）或术前用药的丙泊酚组（MP组）。MS组和MP组在诱导前30分钟口服咪达唑仑0.5mg·kg-1和法莫替丁1mg·kg-1。评估麻醉恢复、躁动和术后疼痛情况。记录从手术结束到拔管以及出院的时间间隔。还检查呕吐发生率和镇痛药的使用情况。丙泊酚麻醉的苏醒比七氟醚麻醉慢，但四组之间的出院时间无显著差异。S组的躁动发生率高于P组，但MS组和MP组之间无差异。四组术后疼痛情况相似。呕吐发生率无差异。与七氟醚麻醉相比，丙泊酚麻醉苏醒较慢且躁动较少。
