Veinstein A, Wernet A, Mira J P
Service de réanimation médicale Groupe hospitalier Cochin-Saint-Vincent-de-Paul 75679 Paris.
Rev Prat. 2001 Mar 31;51(6):596-602.
Septic shock is the most severe systemic inflammatory response to infection. Despite recent progress in prevention and critical care therapy, this syndrome is the most common cause of death in intensive care units. Major advances have been realized recently in the understanding of septic shock. Cellular receptors involved in bacterial recognition have been identified as Toll-like receptors. After bacterial challenge, these receptors become activated and initiate in septic shock patients a biphasic immunological response associated with coagulation disorders. Genetic variability among humans and their predisposition towards pathologic inflammatory responses have also been demonstrated. These current views on the pathophysiological aspects of septic shock open new therapeutic perspectives which should change the prognosis of this syndrome.
感染性休克是对感染最严重的全身性炎症反应。尽管在预防和重症监护治疗方面取得了最新进展，但该综合征仍是重症监护病房中最常见的死亡原因。最近在感染性休克的认识方面取得了重大进展。参与细菌识别的细胞受体已被确定为Toll样受体。在细菌攻击后，这些受体被激活，并在感染性休克患者中引发与凝血障碍相关的双相免疫反应。人类之间的基因变异性及其对病理性炎症反应的易感性也已得到证实。这些关于感染性休克病理生理方面的当前观点开启了新的治疗前景，有望改变该综合征的预后。
