Division of Critical Care Medicine, Department of Internal Medicine, Cooper University Hospital, Camden, NJ, USA.
Crit Care Clin. 2009 Oct;25(4):677-702, vii. doi: 10.1016/j.ccc.2009.08.002.
There is a profound cellular dysfunction in sepsis, that clinically manifests as a continuum from simple, uncomplicated sepsis to severe sepsis, and finally to septic shock. Septic shock remains a significant challenge for clinicians. Recent advances in cellular and molecular biology have significantly improved our understanding of its pathogenetic mechanisms. These improvements will translate to better care and improved outcomes for these patients.
脓毒症存在深刻的细胞功能障碍，临床上表现为从简单、非复杂性脓毒症到严重脓毒症，最终到感染性休克的连续过程。感染性休克仍然是临床医生面临的重大挑战。细胞和分子生物学的最新进展极大地提高了我们对其发病机制的理解。这些进展将转化为这些患者更好的护理和改善的结果。
