Kita Y, Nambu H, Ramesh N G, Anilkumar G, Matsugi M
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamada-oka, Suita, Osaka 565-0871, Japan.
Org Lett. 2001 Apr 19;3(8):1157-60. doi: 10.1021/ol010014p.
[reaction: see text]. The combination of water-soluble radical initiator 2,2'-azobis[2-(2-imidazolin-2-yl)propane] (VA-061), water-soluble chain carrier 1-ethylpiperidine hypophosphite (EPHP), and surfactant cetyltrimethylammonium bromide (CTAB) was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates.
[反应：见正文]。发现水溶性自由基引发剂2,2'-偶氮双2-(2-咪唑啉-2-基)丙烷、水溶性链载体次磷酸1-乙基哌啶盐(EPHP)和表面活性剂十六烷基三甲基溴化铵(CTAB)的组合是在水中对多种疏水底物进行有效自由基环化的最合适条件。
