镍催化的串联 Ueno-Stork 环化反应：环状烯烃的立体选择性 1,2-双官能团化。
Nickel-Catalyzed Tandem Ueno-Stork Cyclization: Stereoselective 1,2-Dicarbofunctionalization of Cyclic Alkenes.
机构信息
Department of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.
出版信息
J Org Chem. 2022 Jul 1;87(13):8796-8801. doi: 10.1021/acs.joc.2c00770. Epub 2022 Jun 22.
PMID:35732004
Abstract
A nickel-catalyzed tandem Ueno-Stork cyclization is developed to enable stereoselective 1,2-dicarbofunctionalization of cyclic alkenes and efficiently build various bicyclic products. This new protocol does not involve any toxic or difficult-to-remove tin reagent and is scalable and amenable to build all-carbon quaternary centers.
摘要
发展了一种镍催化的串联 Ueno-Stork 环化反应，实现了环状烯烃的立体选择性 1,2-二羰基官能化，并高效构建了各种双环产物。该新方法不涉及任何有毒或难以去除的锡试剂，且具有可扩展性，并适用于构建全碳季碳原子。
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