Goti A, Cacciarini M, Cardona F, Cordero F M, Brandi A
Dipartimento di Chimica organica "Ugo Schiff", Centro di Studio C.N.R. sulla Chimica e la Struttura dei Composti Eterociclici e loro Applicazioni (CSCEA), Università degli Studi di Firenze, via G. Capponi 9, I-50121 Firenze, Italy.
Org Lett. 2001 May 3;3(9):1367-9. doi: 10.1021/ol015747o.
[reaction in text] Straightforward total syntheses of (-)-rosmarinecine have been achieved from L-malic acid derived pyrroline N-oxides by two novel useful cascade processes, which join the family of domino reactions. Both strategies, which furnished the target alkaloid in enantioenriched and enantiopure forms, respectively, allow complete control of configuration at all the three newly created contiguous stereogenic centers.
通过两种新颖且有用的串联反应，从L-苹果酸衍生的吡咯啉N-氧化物出发，已实现了（-）-迷迭香碱的直接全合成，这两种反应属于多米诺反应家族。这两种策略分别以对映体富集和对映体纯的形式提供目标生物碱，能够完全控制所有三个新生成的相邻立体中心的构型。
