从一个共同的前体中全合成独脚金内酯 A、贝壳杉素、澳洲茄边碱、3-表澳洲茄边碱和 3,7-二表澳洲茄边碱。
Total synthesis of uniflorine A, casuarine, australine, 3-epi-australine, and 3,7-di-epi-australine from a common precursor.
机构信息
School of Chemistry, University of Wollongong, Wollongong, New South Wales, 2522, Australia.
出版信息
J Org Chem. 2010 Feb 5;75(3):815-24. doi: 10.1021/jo902355p.
PMID:20028000
Abstract
A flexible method for the diastereoselective total synthesis of the pyrrolizidine alkaloids uniflorine A, casuarine, australine, and 3-epi-australine and the unnatural epimer 3,7-di-epi-australine from a common chiral 2,5-dihydropyrrole precursor is described.
摘要
描述了一种从常见的手性 2,5-二氢吡咯前体中立体选择性地全合成吡咯里西啶生物碱乌弗林 A、卡西乌林、澳斯丁和 3-表澳斯丁以及非天然对映异构体 3,7-二-表澳斯丁的灵活方法。
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