Hu Y, Yang Z
Harvard Institute of Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, SGM 604, Boston, Massachusetts 02115-5731, USA.
Org Lett. 2001 May 3;3(9):1387-90. doi: 10.1021/ol010033z.
[reaction in text] The carbonylative annulation of o-alkynylphenols mediated by PdCl(2)(PPh(3))(2) and dppp in the presence of CsOAc at 55 degrees C in acetonitrile under a balloon pressure of CO generates functionalized benzo[b]furo[3,4-d]furan-1-ones in good yields. This novel synthetic approach provides a highly efficient method for diversification of the benzofuran scaffold for combinatorial synthesis.
[文本中的反应] 在55℃、乙腈中，于气球压力的CO存在下，由PdCl₂(PPh₃)₂和dppp介导，并在醋酸铯存在下，邻炔基苯酚的羰基化环化反应能以良好产率生成官能化的苯并[b]呋喃并[3,4-d]呋喃-1-酮。这种新颖的合成方法为组合合成中苯并呋喃骨架的多样化提供了一种高效方法。
