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Transition Metal Catalyzed Synthesis of Arylamines and Aryl Ethers from Aryl Halides and Triflates: Scope and Mechanism.过渡金属催化由芳基卤化物和三氟甲磺酸芳基酯合成芳胺和芳基醚：范围与机理
Angew Chem Int Ed Engl. 1998 Aug 17;37(15):2046-2067. doi: 10.1002/(SICI)1521-3773(19980817)37:15<2046::AID-ANIE2046>3.0.CO;2-L.
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The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4.康普他汀A4的查耳酮、茚满酮和茚酮类似物的简洁合成。
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Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases.新型模板3,7-二苯基-4-氨基噻吩并和呋喃并-[3,2-c]吡啶作为蛋白激酶抑制剂的设计与有效合成以及针对血管生成激酶的体外评估
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The selective reaction of aryl halides with KOH: synthesis of phenols, aromatic ethers, and benzofurans.芳基卤化物与氢氧化钾的选择性反应：酚类、芳香醚和苯并呋喃的合成。
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Solid-phase synthesis of 2,3-disubstituted benzo[b]thiophenes and benzo[b]selenophenes.2,3-二取代苯并[b]噻吩和苯并[b]硒吩的固相合成
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Synthesis of 2,3-disubstituted benzo[b]furans by the palladium-catalyzed coupling of o-iodoanisoles and terminal alkynes, followed by electrophilic cyclization.通过钯催化的邻碘苯甲醚与末端炔烃的偶联反应，随后进行亲电环化反应合成2,3-二取代苯并[b]呋喃。
J Org Chem. 2005 Dec 9;70(25):10292-6. doi: 10.1021/jo051299c.
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Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.用于治疗骨关节炎的强效、选择性且口服生物可利用的基质金属蛋白酶-13抑制剂。
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Carbon-carbon bonding made easy.碳-碳键合变得容易。
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Novel PdII-mediated cascade carboxylative annulation to construct benzo[b]furan-3-carboxylic acids.新型钯（II）介导的级联羧基环化反应构建苯并[b]呋喃-3-羧酸。
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Structure-activity relationships of arylbenzofuran H3 receptor antagonists.芳基苯并呋喃H3受体拮抗剂的构效关系
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多取代苯并[b]呋喃库的平行合成

Parallel synthesis of a multi-substituted benzo[b]furan library.

作者信息

Cho Chul-Hee, Neuenswander Benjamin, Lushington Gerald H, Larock Richard C

机构信息

Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.

出版信息

J Comb Chem. 2008 Nov-Dec;10(6):941-7. doi: 10.1021/cc800120y. Epub 2008 Oct 21.

DOI:10.1021/cc800120y
PMID:18937516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2669318/
Abstract

The solution-phase parallel synthesis of a 121-member library of multi-substituted benzo[ b]furans is described. 2,3,5-Trisubstituted benzo[ b]furans have been prepared by the palladium-catalyzed substitution of 3-iodobenzofurans by Suzuki-Miyaura, carbonylative Suzuki, Sonogashira, Heck, and carboalkoxylation chemistry. The 3-iodobenzofurans are readily prepared in good to excellent yields by the palladium/copper-catalyzed cross-coupling of various o-iodoanisoles and terminal alkynes, followed by electrophilic cyclization with ICl.

摘要

本文描述了一个由121个成员组成的多取代苯并[b]呋喃库的溶液相平行合成。通过钯催化3-碘代苯并呋喃与铃木-宫浦反应、羰基化铃木反应、园田-薗头反应、赫克反应和碳烷氧基化反应进行取代反应，制备了2,3,5-三取代苯并[b]呋喃。通过钯/铜催化各种邻碘苯甲醚与末端炔烃的交叉偶联反应，随后用ICl进行亲电环化反应，可以很容易地以良好到优异的产率制备3-碘代苯并呋喃。