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实验室小鼠中获得性曼氏血吸虫抗性的被动转移

Passive transfer of acquired resistance to Schistosoma mansoni in laboratory mice.

作者信息

Sher A, Smithers S R, Mackenzie P

出版信息

Parasitology. 1975 Jun;70 Part 3:347-57. doi: 10.1017/s0031182000052124.

DOI:10.1017/s0031182000052124
PMID:1134831
Abstract

Serum taken from mice 12-15 weeks after a primary infection of Schistosoma mansoni transfers to normal recipients a partial resistance to subsequent schistosome challenge. The transfer of immunity is evident not only in the reduced recovery of mature parasites from the liver, but also in the diminished numbers of invading schistosomula recovered of resistance equivalent on average to 47% of that found in actively immunized animals, the results suggest that humoral factors play a major role in the effector mechanism of schistosome immunity.

摘要

在曼氏血吸虫初次感染12 - 15周后从小鼠采集的血清,可将对后续血吸虫攻击的部分抗性传递给正常受体。免疫传递不仅表现为从肝脏中回收的成熟寄生虫数量减少,还表现为回收的入侵血吸虫幼虫数量减少,平均抗性相当于主动免疫动物的47%。结果表明,体液因子在血吸虫免疫的效应机制中起主要作用。

相似文献

1
Passive transfer of acquired resistance to Schistosoma mansoni in laboratory mice.实验室小鼠中获得性曼氏血吸虫抗性的被动转移
Parasitology. 1975 Jun;70 Part 3:347-57. doi: 10.1017/s0031182000052124.
2
A role for the eosinophil in acquired resistance to Schistosoma mansoni infection as determined by antieosinophil serum.抗嗜酸性粒细胞血清所确定的嗜酸性粒细胞在获得性曼氏血吸虫感染抗性中的作用。
J Exp Med. 1975 Oct 1;142(4):805-13. doi: 10.1084/jem.142.4.805.
3
Acquired immunity to Schistosoma mansoni in the rat: measurement of immunity by the lung recovery technique.大鼠对曼氏血吸虫的获得性免疫:通过肺回收技术测定免疫力。
Parasitology. 1974 Dec;69(3):349-59. doi: 10.1017/s0031182000063046.
4
Adoptive transfer of protective immunity in experimental schistosomiasis in the mouse.
J Parasitol. 1979 Aug;65(4):515-9.
5
Failure of plasma from human schistosomiasis mansoni patients to protect mice from Schistosoma mansoni cercarial challenge.曼氏血吸虫病患者的血浆未能保护小鼠免受曼氏血吸虫尾蚴攻击。
Am J Trop Med Hyg. 1977 Jul;26(4):723-6. doi: 10.4269/ajtmh.1977.26.723.
6
Passive transfer of resistance and the site of immune-dependent elimination of the challenge infection in rats vaccinated with highly irradiated cercariae of Schistosoma mansoni.用曼氏血吸虫高度辐照尾蚴免疫的大鼠中抗性的被动转移及免疫依赖性消除攻击感染的部位
Parasitology. 1984 Dec;89 ( Pt 3):461-82. doi: 10.1017/s0031182000056705.
7
Induction of protective immunity against Schistosoma mansoni by a non living vaccine. I. Partial characterization of antigens recognized by antibodies from mice immunized with soluble schistosome extracts.非活性疫苗诱导针对曼氏血吸虫的保护性免疫。I. 用可溶性血吸虫提取物免疫的小鼠产生的抗体所识别抗原的部分特性分析
J Immunol. 1985 May;134(5):3432-8.
8
Schistosomiasis from S. mansoni in mice: the relationship between acquired immunity and serum levels of lethal antibody.小鼠曼氏血吸虫引起的血吸虫病:获得性免疫与致死性抗体血清水平之间的关系。
Parasite Immunol. 1981 Winter;3(4):319-27. doi: 10.1111/j.1365-3024.1981.tb00410.x.
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Schistosoma mansoni: in vitro and in vivo killing of antibody-coated schistosomula.曼氏血吸虫:抗体包被的血吸虫童虫在体外和体内的杀伤作用
Am J Trop Med Hyg. 1982 Sep;31(5):991-8. doi: 10.4269/ajtmh.1982.31.991.
10
Histological examination of the cellular reactions around schistosomula of Schistosoma mansoni in the lungs of sublethally irradiated and unirradiated, immune and control rats.
Parasitology. 1989 Feb;98 ( Pt 1):57-65. doi: 10.1017/s0031182000059680.

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Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4.曼氏血吸虫成虫抗原的人抗体 IgA、IgE、IgG1 和 IgG4 的差异识别模式。
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T follicular helper cells differentiate from Th2 cells in response to helminth antigens.
滤泡辅助性T细胞在对蠕虫抗原的应答中从Th2细胞分化而来。
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Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells.在曼氏血吸虫病小鼠模型中,白细胞介素5(IL-5)对于Th2反应的表达或宿主抵抗机制并非必需,但在产生IL-4的非T、非B细胞的发育中发挥作用。
Infect Immun. 1999 Jun;67(6):3014-8. doi: 10.1128/IAI.67.6.3014-3018.1999.
5
Functional studies on purified eosinophils and neutrophils from patients with Schistosoma mansoni infections.对曼氏血吸虫感染患者纯化嗜酸性粒细胞和中性粒细胞的功能研究。
Clin Exp Immunol. 1980 Mar;39(3):683-94.
6
Quantification, dynamics, and mechanisms of pulmonary inflammatory response around schistosomula of Schistosoma mansoni.曼氏血吸虫童虫周围肺部炎症反应的量化、动态变化及机制
Am J Pathol. 1981 Aug;104(2):150-8.
7
Identification of surface antigens of schistosomula of Schistosoma mansoni recognized by antibodies from mice immunized by chronic infection and by exposure to highly irradiated cercariae.曼氏血吸虫童虫表面抗原的鉴定,这些抗原可被经慢性感染免疫的小鼠以及经高度辐照尾蚴暴露的小鼠产生的抗体所识别。
Infect Immun. 1983 Aug;41(2):591-7. doi: 10.1128/iai.41.2.591-597.1983.
8
A role for the eosinophil in acquired resistance to Schistosoma mansoni infection as determined by antieosinophil serum.抗嗜酸性粒细胞血清所确定的嗜酸性粒细胞在获得性曼氏血吸虫感染抗性中的作用。
J Exp Med. 1975 Oct 1;142(4):805-13. doi: 10.1084/jem.142.4.805.
9
Induction of cellular and humoral immunological responsiveness to a soluble cercarial antigen preparation from Schistosoma mansoni.诱导对来自曼氏血吸虫的可溶性尾蚴抗原制剂的细胞免疫和体液免疫反应性。
Infect Immun. 1976 Aug;14(2):502-8. doi: 10.1128/iai.14.2.502-508.1976.
10
Eosinophil-enriched inflammatory response to schistosomula in the skin of mice immune to Schistosoma mansoni.对曼氏血吸虫免疫的小鼠皮肤中,嗜酸性粒细胞富集的炎性反应针对血吸虫童虫。
Am J Pathol. 1976 Sep;84(3):479-500.