Plotkin S A
Aventis Pasteur, Wistar Institute, University of Pennsylvania, 4650 Wismer Road, Doylestown, PA 18901, USA.
Vaccine. 2001 May 14;19(25-26):3311-9. doi: 10.1016/s0264-410x(01)00073-1.
The virulence of rubella virus for the fetus was fully defined between 1963 and 1965 when an epidemic of rubella occurred in Europe and the US, followed by a wave of damaged babies. Attenuated live virus vaccines were developed in our and other laboratories and their use has already considerably changed the epidemiology of rubella. Nevertheless, only about half of the world's countries vaccinate against rubella. We argue for the combination of rubella vaccine with measles vaccine in all campaigns for the control of measles, and will discuss the strategies by which congenital rubella syndrome could be eradicated at little additional cost.
1963年至1965年间，风疹病毒对胎儿的致病性得到了充分明确。当时，欧洲和美国爆发了风疹疫情，随后出现了一波先天缺陷婴儿潮。我们实验室和其他实验室研发出了减毒活疫苗，其使用已经极大地改变了风疹的流行病学特征。然而，全球只有约一半的国家接种风疹疫苗。我们主张在所有控制麻疹的活动中，将风疹疫苗与麻疹疫苗联合使用，并将讨论以较低额外成本根除先天性风疹综合征的策略。
