铜绿假单胞菌角膜感染期间外源性白细胞介素-6的作用
Effects of exogenous interleukin-6 during Pseudomonas aeruginosa corneal infection.
作者信息
Cole N, Krockenberger M, Bao S, Beagley K W, Husband A J, Willcox M
机构信息
Co-Operative Research Center for Eye Research and Technology, Cornea and Contact Lens Research Unit and School of Optometry, University of New South Wales, Sydney, Australia.
出版信息
Infect Immun. 2001 Jun;69(6):4116-9. doi: 10.1128/IAI.69.6.4116-4119.2001.
Abstract
Lack of interleukin-6 (IL-6) during Pseudomonas aeruginosa corneal infection leads to more severe disease with changes in neutrophil recruitment. Exogenous IL-6 leads to increased efficiency of neutrophil recruitment and reduced bacterial loads in corneal infection in both IL-6 gene knockout and wild-type mice. This may be mediated by IL-6 increasing the production of corneal macrophage inflammatory protein 2 and intercellular cell adhesion molecule 1. We conclude that effective recruitment of neutrophils into the cornea is dependent on the production of IL-6 and that early augmentation of IL-6 may be protective in corneal infection.
摘要
铜绿假单胞菌角膜感染期间白细胞介素-6（IL-6）的缺乏会导致病情更严重，同时中性粒细胞募集发生变化。在IL-6基因敲除小鼠和野生型小鼠的角膜感染中，外源性IL-6可提高中性粒细胞募集效率并降低细菌载量。这可能是由IL-6增加角膜巨噬细胞炎性蛋白2和细胞间细胞黏附分子1的产生介导的。我们得出结论，中性粒细胞有效募集到角膜中依赖于IL-6的产生，并且早期增加IL-6可能对角膜感染具有保护作用。
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