非孕期女性与正常妊娠、子痫前期或妊娠期高血压女性的迷走神经压力反射功能比较。

Comparison of vagal baroreflex function in nonpregnant women and in women with normal pregnancy, preeclampsia, or gestational hypertension.

作者信息

Silver H M, Tahvanainen K U, Kuusela T A, Eckberg D L

机构信息

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island 02905, USA.

出版信息

Am J Obstet Gynecol. 2001 May;184(6):1189-95. doi: 10.1067/mob.2001.112871.

DOI:10.1067/mob.2001.112871

PMID:11349187

Abstract

OBJECTIVE

Our aim was to compare baroreflex function among nonpregnant women and among women with normal pregnancy, preeclampsia, or gestational hypertension.

STUDY DESIGN

Baroreflex function was tested in 20 women with preeclampsia, in 20 age- and gestational age-matched normotensive gravid women, in 20 age-matched nonpregnant women, and in 20 nonmatched women with gestational hypertension. The baroreflex was measured by several modalities.

RESULTS

Vagal baroreflex gain measured by cross-spectral analysis of parallel spontaneous heart rate and blood pressure changes is significantly decreased in normal pregnancy (15.8 +/- 7.2 vs 10.8 +/- 4.1 ms/mm Hg; P = 0.001), in comparison with vagal baroreflex gain in nonpregnant women. Baroreflex gain is further reduced in preeclamptic pregnancy (10.8 +/- 4.1 vs 7.2 +/- 2.6 ms/mm Hg; P = 0.003) and in gestational hypertension (10.8 +/- 4.1 vs 6.5 +/- 2.7 ms/mm Hg; P = 0.001), compared with that in normal pregnancy. Similar differences were seen with other baroreflex testing modalities.

CONCLUSIONS

The normal reduction of baroreflex gain in pregnancy is further depressed in subjects with hypertensive disorders of pregnancy.

摘要

目的

我们的目的是比较未怀孕女性、正常妊娠女性、先兆子痫女性或妊娠高血压女性的压力反射功能。

研究设计

对20例先兆子痫女性、20例年龄和孕周匹配的血压正常的妊娠女性、20例年龄匹配的未怀孕女性以及20例未匹配的妊娠高血压女性进行压力反射功能测试。通过多种方式测量压力反射。

结果

与未怀孕女性的迷走神经压力反射增益相比，正常妊娠时通过对平行的自发心率和血压变化进行互谱分析测得的迷走神经压力反射增益显著降低（15.8±7.2对10.8±4.1毫秒/毫米汞柱；P = 0.001）。与正常妊娠相比，先兆子痫妊娠（10.8±4.1对7.2±2.6毫秒/毫米汞柱；P = 0.003）和妊娠高血压（10.8±4.1对6.5±2.7毫秒/毫米汞柱；P = 0.001）时压力反射增益进一步降低。其他压力反射测试方式也观察到类似差异。