Liu Yueh-Ling, Chang Chien-Hsiang
Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan, 70101, Republic of China
J Colloid Interface Sci. 2001 Jun 1;238(1):85-90. doi: 10.1006/jcis.2001.7493.
The influence of tyloxapol on the dynamic surface tension response of dipalmitoyl phosphatidylcholine (DPPC) dispersions at pulsating air/liquid interfaces was investigated. For a 1000 ppm DPPC dispersion prepared by sonication with a larger particle size, the dynamic surface activity of DPPC was strongly affected by the addition of 100 ppm tyloxapol. With a longer sonication time or smaller particle size, the DPPC inactivation was still observed but was somewhat less significant, resulting in slightly lower dynamic surface tensions. If a DPPC dispersion was sonicated in the presence of tyloxapol, the particle size of DPPC was greatly reduced by tyloxapol and the inhibitory effect of tyloxapol on the dynamic adsorption of DPPC may be significantly diminished. The results suggest that the competitive adsorption of tyloxapol may have a detrimental effect on the dynamic surface tension lowering ability of a DPPC dispersion with the extent depending on the DPPC dispersion state. Nevertheless, the dynamic surface activity of DPPC may be enhanced through the improved dispersion by tyloxapol if an appropriate preparation protocol is applied, and the inhibitory effect of tyloxapol may be reduced or overcome. Copyright 2001 Academic Press.
研究了泰洛沙泊对二棕榈酰磷脂酰胆碱（DPPC）分散体在脉动气/液界面处动态表面张力响应的影响。对于通过超声处理制备的粒径较大的1000 ppm DPPC分散体，添加100 ppm泰洛沙泊会强烈影响DPPC的动态表面活性。超声处理时间越长或粒径越小，仍会观察到DPPC失活，但不太明显，导致动态表面张力略低。如果在泰洛沙泊存在下对DPPC分散体进行超声处理，泰洛沙泊会使DPPC的粒径大大减小，并且泰洛沙泊对DPPC动态吸附的抑制作用可能会显著减弱。结果表明，泰洛沙泊的竞争性吸附可能会对DPPC分散体降低动态表面张力的能力产生不利影响，其程度取决于DPPC的分散状态。然而，如果采用适当的制备方案，通过泰洛沙泊改善分散性可增强DPPC的动态表面活性，并且泰洛沙泊的抑制作用可能会降低或克服。版权所有2001年学术出版社。
