Tataru M C, Schulte H, von Eckardstein A, Heinrich J, Assmann G, Koehler E
Herz- und Gefässklinik, Bad Neustadt an der Saale, Rhön-Klinikum AG, D-Bad Neustadt, Germany.
Coron Artery Dis. 2001 May;12(3):157-65. doi: 10.1097/00019501-200105000-00001.
Authors both of retrospective and of prospective studies have demonstrated that there is a relationship between concentration of fibrinogen in plasma and the angiographically determined severity of coronary heart disease (CHD).
To determine the relevance of the plasma fibrinogen concentration for the severity of CHD, particularly in cases with additional arteriosclerotic changes in the extracranial arteries supplying the brain [cerebrovascular disease (CVD)], in the pelvic/leg arteries [peripheral occlusive arterial disease (POAD)], or in both.
In a retrospective cross-sectional survey the cardiological and angiographical status of a total of 1112 male and 299 female patients with stable angina pectoris after sustained myocardial infarction and an age-matched control group of 326 male and 138 female subjects with no clinical symptoms of CHD was determined, together with measurements of plasma fibrinogen, dynamic plasma viscosity and D-dimers.
More than two-thirds of the patients with arteriosclerosis had plasma fibrinogen concentrations in the uppermost tertile of the control range (men > 2.75; women > 2.83 g/l). Plasma fibrinogen concentration was correlated to the severity of CHD (for men r = 0.173, P < 0.001; for women r= 0.144, P < 0.013). Patients with generalized arteriosclerosis had higher plasma fibrinogen concentrations than did those suffering from CHD only (for men, control 2.65 +/- 0.51, CHD 3.07 +/- 0.73, CHD plus POAD 3.17 +/- 0.77 and CHD plus POAD plus CVD 3.45 +/- 0.78 g/l; for women, control 2.69 +/- 0.44, CHD 3.25 +/- 0.67, CHD plus POAD 3.19 +/- 0.77, CHD plus POAD plus CVD 3.60 +/- 0.84 g/l). Multivariate analysis showed that C-reactive protein, D-dimers and dynamic plasma viscosity accounted for 48.2% (for men) and 49.4% (for women) of the variance in plasma fibrinogen concentration.
Our findings demonstrate that there is not only a correlation between plasma fibrinogen concentration and the severity of CHD, but also a correlation to the incidence of additional POAD or CVD.
回顾性研究和前瞻性研究的作者均已证明，血浆中纤维蛋白原浓度与冠状动脉造影确定的冠心病（CHD）严重程度之间存在关联。
确定血浆纤维蛋白原浓度与冠心病严重程度的相关性，尤其是在供应脑部的颅外动脉[脑血管疾病（CVD）]、盆腔/腿部动脉[周围闭塞性动脉疾病（POAD）]或两者均有动脉硬化改变的情况下。
在一项回顾性横断面调查中，确定了总共1112例男性和299例女性持续性心肌梗死后稳定型心绞痛患者的心脏病学和血管造影状况，以及年龄匹配的326例男性和138例女性无冠心病临床症状的对照组，并测量了血浆纤维蛋白原、动态血浆粘度和D - 二聚体。
超过三分之二的动脉硬化患者血浆纤维蛋白原浓度处于对照范围的最高三分位数（男性>2.75；女性>2.83 g/l）。血浆纤维蛋白原浓度与冠心病严重程度相关（男性r = 0.173，P < 0.001；女性r = 0.144，P < 0.013）。全身性动脉硬化患者的血浆纤维蛋白原浓度高于仅患有冠心病的患者（男性，对照组2.65±0.51，冠心病组3.07±0.73，冠心病加POAD组3.17±0.77，冠心病加POAD加CVD组3.45±0.78 g/l；女性，对照组2.69±0.44，冠心病组3.25±0.67，冠心病加POAD组3.19±0.77，冠心病加POAD加CVD组3.60±0.84 g/l）。多变量分析表明，C反应蛋白、D - 二聚体和动态血浆粘度占血浆纤维蛋白原浓度方差的48.2%（男性）和49.4%（女性）。
我们的研究结果表明，血浆纤维蛋白原浓度不仅与冠心病严重程度相关，而且与额外的POAD或CVD发病率相关。
