Morris J S, Buchel C, Dolan R J
Wellcome Department of Cognitive Neurology, Queen Square, London WC1N 3BG, United Kingdom.
Neuroimage. 2001 Jun;13(6 Pt 1):1044-52. doi: 10.1006/nimg.2000.0721.
We used event-related fMRI to measure neural activity in volunteer subjects during acquisition of an implicit association between a visual conditioned stimulus (CS+) (angry face) and an auditory unconditioned stimulus (UCS) (aversive, loud noise). Three distinct functional regions were identified within left amygdala: a UCS (noise)-related lateral region, a CS+-related ventral region, and a dorsal region where CS+-related responses changed progressively across the learning session. Differential neural responses to the visual CS+ were also evoked in extrastriate and auditory cortices. Our results indicate that learning an association between biologically salient stimuli of different sensory modalities involves parallel changes of neural activity in segregated amygdala subregions and unimodal sensory cortices.
我们使用事件相关功能磁共振成像技术来测量志愿者在习得视觉条件刺激（CS+）（愤怒面孔）与听觉非条件刺激（UCS）（厌恶的大声噪音）之间的隐性关联过程中的神经活动。在左侧杏仁核内确定了三个不同的功能区域：一个与UCS（噪音）相关的外侧区域、一个与CS+相关的腹侧区域，以及一个背侧区域，在整个学习过程中，与CS+相关的反应在该背侧区域逐渐变化。在纹外皮层和听觉皮层也诱发了对视觉CS+的不同神经反应。我们的结果表明，学习不同感觉模态的生物学显著刺激之间的关联涉及杏仁核不同亚区域和单峰感觉皮层中神经活动的平行变化。
