Viola R E
Department of Chemistry, University of Toledo, Toledo, Ohio 43606, USA.
Acc Chem Res. 2001 May;34(5):339-49. doi: 10.1021/ar000057q.
The aspartate pathway is responsible for the biosynthesis of lysine, threonine, isoleucine, and methionine in most plants and microorganisms. The absence of this pathway in humans and animals makes the central enzymes potential targets for inhibition, with the aim of developing new herbicides and biocides, and also for enhancement, to improve the nutritional value of crops. Our current state of knowledge of these enzymes is reviewed, including recently determined structural information and newly constructed bifunctional fusion enzymes.
天冬氨酸途径负责大多数植物和微生物中赖氨酸、苏氨酸、异亮氨酸和蛋氨酸的生物合成。人和动物体内缺乏该途径，这使得该途径中的关键酶成为抑制的潜在靶点，目的是开发新的除草剂和杀虫剂，同时也是为了增强该途径以提高作物的营养价值。本文综述了我们目前对这些酶的了解情况，包括最近确定的结构信息和新构建的双功能融合酶。
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