Jordan J
Franz-Volhard-Clinic, Haus 129, Humboldt University, Wiltbergstr. 50, 13125 Berlin, Germany.
Curr Hypertens Rep. 2001 Jun;3(3):216-26. doi: 10.1007/s11906-001-0041-7.
Nonpharmacologic and pharmacologic treatment can significantly attenuate the symptoms of orthostatic hypotension. Some of the interventions that are used to treat orthostatic hypotension have been known for decades. However, several new treatment strategies have been developed in recent years. New knowledge about the pathophysiology of orthostatic syndromes has been gathered that will strongly influence the way treatments are tailored to individual patients. For example, patients with and without residual autonomic function exhibit differential responses to certain treatments. A large subgroup of patients with severe autonomic failure show a profound pressor response to water drinking. This simple effect can be exploited to treat orthostatic and postprandial hypotension in some patients. New bioengineering technologies that attempt to replicate normal baroreflex mechanisms may become available for selected patients with central autonomic dysfunction.
非药物治疗和药物治疗可显著减轻体位性低血压的症状。一些用于治疗体位性低血压的干预措施已为人所知数十年。然而，近年来已开发出几种新的治疗策略。关于体位性综合征病理生理学的新知识不断积累，这将极大地影响针对个体患者量身定制治疗方案的方式。例如，有和没有残余自主神经功能的患者对某些治疗表现出不同的反应。一大亚组严重自主神经功能衰竭患者对饮水表现出强烈的升压反应。这种简单的效应可用于治疗部分患者的体位性和餐后低血压。试图复制正常压力反射机制的新生物工程技术可能会应用于部分患有中枢自主神经功能障碍的患者。
