Badr F M, Barcikowski B, Bartke A
Prostaglandins. 1975 Feb;9(2):289-97. doi: 10.1016/0090-6980(75)90033-7.
The concentration of prostaglandins E and F in different parts of the male reproductive system of CD-1 and dwarf mice was measured by radioimmunoassay. In intact CD-1 mice, the vas deferens contained a significantly higher concentration of PGE and PGF than was found in the epididymis and in the seminal vesicles. All tissues studied had more PGE than PGF. Castration resulted in increased PG concentrations in both the epididymis and the seminal vesicles and decreased PG concentrations in the vas deferens. There was also a differential response of PGE and PGF in the epididymis of genetically sterile dwarf mice (dw/dw) were significantly higher than those observed in their normal littermates ((PLUS)). A reversed PGE/PGF ratio was found in the mates. The results indicate that testicular androgens affect the levels of PGE and PGF in the reproductive system of male mice. The physiological role of PGs in male reproductive functions has not been established, but there is a suggestion that PH have a role in controlling the transit of spermatozoa through the epididymis and vas deferens.
采用放射免疫分析法测定了CD-1小鼠和侏儒小鼠雄性生殖系统不同部位前列腺素E和F的浓度。在完整的CD-1小鼠中，输精管中前列腺素E和F的浓度显著高于附睾和精囊中发现的浓度。所有研究的组织中前列腺素E都比前列腺素F多。去势导致附睾和精囊中前列腺素浓度升高，输精管中前列腺素浓度降低。在基因不育的侏儒小鼠（dw/dw）的附睾中，前列腺素E和F也有不同的反应，其浓度显著高于在其正常同窝小鼠（（PLUS））中观察到的浓度。在配偶中发现了相反的前列腺素E/前列腺素F比值。结果表明，睾丸雄激素影响雄性小鼠生殖系统中前列腺素E和F的水平。前列腺素在雄性生殖功能中的生理作用尚未确定，但有人认为前列腺素在控制精子通过附睾和输精管的转运中起作用。
