Armuth V, Berenblum I
J Natl Cancer Inst. 1979 Oct;63(4):1047-50.
A single oral administration of 7,12-dimethylbenz[a]anthracene (DMBA) 2 weeks after intrasplenic grafting of ovarian tissue in unilaterally ovariectomized C3HeB/Fe mice resulted in a high tumor incidence (47%) in the grafted tissue, with only 1 tumor (3%) in the orthotopic ovary. No tumors were seen in the control group (unilaterally ovariectomized mice given intrasplenic grafts of ovarian tissue without subsequent DMBA administration), nor did tumors develop in response to DMBA treatment in mice with both ovaries in situ and no grafted tissue in the spleen. The results indicated that some local change caused by the grafting procedure rendered the tissues more sensitive to the action of DMBA and/or more responsive to gonadotropic stimulation.
在单侧卵巢切除的C3HeB/Fe小鼠脾内移植卵巢组织两周后，单次口服7,12-二甲基苯并[a]蒽（DMBA），结果移植组织中肿瘤发生率很高（47%），而原位卵巢中只有1个肿瘤（3%）。对照组（单侧卵巢切除的小鼠接受脾内卵巢组织移植但未随后给予DMBA）未出现肿瘤，双侧卵巢原位且脾内无移植组织的小鼠对DMBA治疗也未发生肿瘤。结果表明，移植手术引起的一些局部变化使组织对DMBA的作用更敏感和/或对促性腺激素刺激反应更强。
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