Edelmann J, Szibor R
Institute of Legal Medicine, University of Leipzig, Johannisallee 28, 04103 Leipzig, Germany.
Int J Legal Med. 2001;114(4-5):301-4. doi: 10.1007/s004140000188.
This paper presents sequence and population genetic data for the microsatellite marker DXS101 which is a highly polymorphic X-linked trinucleotide polymorphism with 18 alleles 179-233 bp in length. A polymorphism information content (PIC) of 0.884 and a mean exclusion chance (MEC) of 0.879 were obtained by analysing a Caucasian population sample. A deviation from the Hardy-Weinberg equilibrium (HWE) could not be detected. Kinship tests revealed a typical X-linked inheritance and no mutations were found in 340 meioses. DXS101 is located 104.9-121 cM from the Xp-telomere (Xp-tel) corresponding to Xq21.33-Xq22.3. Concomitant testing of DXS101 and DXS6807 is possible as these two markers are unlinked. The data presented qualify this X-linked microsatellite marker as a useful tool for forensic purposes.
本文展示了微卫星标记DXS101的序列和群体遗传数据，该标记是一种高度多态的X连锁三核苷酸多态性，有18个等位基因，长度在179 - 233 bp之间。通过分析一个白种人群体样本，获得了多态信息含量（PIC）为0.884，平均排除概率（MEC）为0.879。未检测到偏离哈迪-温伯格平衡（HWE）的情况。亲缘关系测试显示典型的X连锁遗传，在340次减数分裂中未发现突变。DXS101位于距Xp端粒（Xp-tel）104.9 - 121 cM处，对应于Xq21.33 - Xq22.3。由于这两个标记不连锁，因此可以同时检测DXS101和DXS6807。所呈现的数据表明这个X连锁微卫星标记是法医鉴定的有用工具。
