Slawecki C J, Betancourt M, Cole M, Ehlers C L
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Brain Res Dev Brain Res. 2001 May 31;128(1):63-72. doi: 10.1016/s0165-3806(01)00150-x.
Most individuals have their first experience with ethanol (EtOH) consumption as adolescents. Episodes of high EtOH drinking, lasting from hours to days (i.e. binges), are not uncommon. Thus, adolescent EtOH drinking has become a significant health concern due to the possible protracted effects of high doses of EtOH on behavior and the developing brain. This study assessed the effects of brief high levels of EtOH during periadolescence on subsequent behavior and electrophysiology in adult rats. Male Sprague-Dawley rats were exposed to EtOH vapor for 5 days (i.e. postnatal days 35-40) or 10 days (i.e. postnatal days 30-40) for 12 h/day. Locomotor activity, EEG activity, and event-related potentials (ERPs) were then assessed at 1 and 6-7 weeks post EtOH exposure. Significant differences in locomotor activity were not observed at 1 week or 6-7 weeks post-ethanol exposure. However, EtOH exposure did have long-term electrophysiological effects. EtOH exposure increased the frequency of the EEG in the 1-2 Hz range in the parietal cortex and the 16-32 Hz range in the hippocampus. EtOH exposure also increased hippocampal N2 amplitude, decreased hippocampal P3 amplitude, and decreased cortical and hippocampal P2 amplitudes. While these findings are generally similar to those reported following long-term ethanol exposure during adulthood, alcohol exposure during adolescence appears to produce more robust hippocampal effects following shorter periods of exposure. In addition, these data indicate that, in the absence of overt behavioral differences, there are long-lasting changes in the functional brain activity of adult rats briefly exposed to high levels of EtOH during the periadolescent period.
大多数人首次接触乙醇（EtOH）是在青少年时期。持续数小时至数天的高剂量EtOH饮酒（即暴饮）并不罕见。因此，由于高剂量EtOH对行为和发育中的大脑可能产生长期影响，青少年EtOH饮酒已成为一个重大的健康问题。本研究评估了青春期前后短期高剂量EtOH对成年大鼠后续行为和电生理学的影响。雄性Sprague-Dawley大鼠每天暴露于EtOH蒸汽中12小时，持续5天（即出生后第35 - 40天）或10天（即出生后第30 - 40天）。然后在EtOH暴露后1周和6 - 7周评估运动活动、脑电图（EEG）活动和事件相关电位（ERP）。在乙醇暴露后1周或6 - 7周未观察到运动活动的显著差异。然而，EtOH暴露确实有长期的电生理效应。EtOH暴露增加了顶叶皮质1 - 2Hz范围内EEG的频率以及海马体16 - 32Hz范围内EEG的频率。EtOH暴露还增加了海马体N2波幅，降低了海马体P3波幅，并降低了皮质和海马体P2波幅。虽然这些发现总体上与成年期长期乙醇暴露后的报告结果相似，但青春期饮酒似乎在较短暴露期后会对海马体产生更显著的影响。此外，这些数据表明，在没有明显行为差异的情况下，青春期前后短暂暴露于高剂量EtOH的成年大鼠的功能性脑活动存在长期变化。
