[Metabolism and toxicity of therapeutic chelating agents. 14. Effect of DTPA on hematopoiesis].

By use of 3-H-thymidine it is shown that toxic doses of Ca-DTPA lead to a reversible inhibition of DNA-synthesis in the lymphocytes, erythro- and myelopoietic cells of the rat. The incorporation of 59-Fe into the erythrocytes is markedly imparied. The hematological reaction, i. e. granulocytosis, lympho- and eosinopenia, is ascribed to the general adaptation syndrom. Zn-DTPA proved to be ineffective in all respects.