Lohbreier J
Strahlentherapie. 1977 Oct;153(10):704-10.
Single subcutaneous injection of Ca-DTPA by a toxic dosage results with rats in a short-term moderate reduction of the plasma concentration of factors belonging to the endogenous coagulation system and of the prothrombin complex. Neither the temporary fibrinolysis nor the thrombocytopenia occurring later deeply affect coagulation as a whole. By fractionation of the daily dose or by continuous infusion of Ca-DTPA damage to the plasmatic coagulation system is not further increased, although the intensity of thrombocytopenia is enhanced which is miminum after single administration of the chelate. The platelet functions, on the other hand, are not influenced by Ca-DTPA. The much better compatibility of Zn-DTPA as compared to Ca-DTPA was fully confirmed also with respect to the hematological and coagulation parameters.
以中毒剂量对大鼠单次皮下注射Ca-DTPA，会导致内源性凝血系统因子和凝血酶原复合物的血浆浓度在短期内适度降低。随后出现的短暂纤维蛋白溶解和血小板减少均未对整体凝血产生严重影响。通过分剂量给药或持续输注Ca-DTPA，虽然血小板减少的强度会增强（单次注射螯合物后血小板减少强度最小），但血浆凝血系统的损伤并未进一步加重。另一方面，血小板功能不受Ca-DTPA影响。在血液学和凝血参数方面，Zn-DTPA与Ca-DTPA相比具有更好的耐受性也得到了充分证实。
