氧化磷酸化途径的线粒体多肽作为抗癌治疗的潜在新靶点。

Mitochondrial polypeptides of the oxidative phosphorylation pathway as potential new targets for anti-cancer therapy.

作者信息

Tarantul V Z, Hunsmann G

机构信息

Department of Viral and Cellular Molecular Genetics, Institute of Molecular Genetics, Moscow, Russia.

出版信息

Med Hypotheses. 2001 Mar;56(3):386-7. doi: 10.1054/mehy.2000.1234.

DOI:10.1054/mehy.2000.1234

PMID:11359366

Abstract

We have analyzed our own results on upregulated gene expression in human and monkey lymphomas as well as the data published on expression levels of genes in various cancer cells. The analysis suggests an important role of particular subunits of oxidative phosphorylation (OXPHOS) proteins in malignant transformation of the cell. It opens a possibility of designing new anti-cancer drugs aimed at specific inhibition of the expression of definite mitochondrial OXPHOS proteins' subunits including those of NADH-dehydrogenase 4, cytochrome c oxidase 1, and cytochrome b.

摘要

我们分析了我们自己关于人类和猴子淋巴瘤中基因表达上调的结果，以及已发表的各种癌细胞中基因表达水平的数据。分析表明氧化磷酸化（OXPHOS）蛋白的特定亚基在细胞恶性转化中起重要作用。这为设计新的抗癌药物开辟了可能性，这些药物旨在特异性抑制特定线粒体OXPHOS蛋白亚基的表达，包括NADH脱氢酶4、细胞色素c氧化酶1和细胞色素b的亚基。