Frank J A, McFarland H F
Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, 10 Center Drive MSC 1074, Bethesda, MD 20892, USA.
Neuroimaging Clin N Am. 2000 Nov;10(4):817-30 ,x.
MR imaging has made a significant contribution to the understanding of the natural history of multiple sclerosis (MS). MR imaging is an important technique for investigating the pathologic process in the MS patient's brain and spinal cord, and it is now considered an essential part of all clinical trials being performed on new agents in the treatment of MS. This article provides an overview for those wishing to become involved in MS clinical research. Discussion includes the use of conventional and newer MR imaging techniques in clinical trials, current thoughts regarding the role of MR imaging as a surrogate outcome measure, and various types of trial designs.
磁共振成像（MR成像）对理解多发性硬化症（MS）的自然病程做出了重大贡献。MR成像是研究MS患者脑和脊髓病理过程的一项重要技术，目前它被视为所有正在进行的MS治疗新药物临床试验的重要组成部分。本文为那些希望参与MS临床研究的人员提供概述。讨论内容包括在临床试验中使用传统和更新的MR成像技术、目前关于MR成像作为替代结局指标作用的观点以及各类试验设计。
