Bakshi Rohit
Center for Neurological Imaging, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Neuroimaging. 2005;15(4 Suppl):5S-9S. doi: 10.1177/1051228405283362.
Magnetic resonance imaging (MRI) has become a core component of clinical management and scientific research in multiple sclerosis (MS), providing essential information about tissue structure and function. MRI is now the most important laboratory diagnostic and longitudinal monitoring technology. A number of conventional MRI techniques, which include T2-weighted, T1-weighted, and gadolinium-enhanced imaging, are used to identify overt lesions and quantify tissue atrophy. MRI is highly sensitive in detecting brain and spinal cord involvement in MS and can visualize multifocal lesions, occult disease, and macroscopic atrophy. Advanced MRI techniques, such as magnetization transfer imaging, spectroscopy, diffusion-weighted imaging, and functional MRI, have added to our understanding of the pathogenesis of the disease. The precise role of these newer imaging approaches continues to be defined. In this supplement to the Journal of Neuroimaging, the authors review the role of conventional and advanced MRI techniques in detecting tissue changes in MS, diagnosing and monitoring patients, and charting the progression of disease in new and established patients.
磁共振成像（MRI）已成为多发性硬化症（MS）临床管理和科研的核心组成部分，可提供有关组织结构和功能的重要信息。MRI现在是最重要的实验室诊断和纵向监测技术。多种传统的MRI技术，包括T2加权成像、T1加权成像和钆增强成像，用于识别明显病变并量化组织萎缩。MRI在检测MS患者脑和脊髓受累方面高度敏感，能够显示多灶性病变、隐匿性疾病和宏观萎缩。先进的MRI技术，如磁化传递成像、波谱分析、扩散加权成像和功能MRI，加深了我们对该疾病发病机制的理解。这些更新的成像方法的确切作用仍有待明确。在《神经影像学杂志》的这份增刊中，作者回顾了传统和先进MRI技术在检测MS组织变化、诊断和监测患者以及描绘新老患者疾病进展方面的作用。
