Sung K F, Tsang N M, Tseng J H, Yeh C T
Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kweishan Hsiang, Taoyuan, Taiwan, R.O.C.
Chang Gung Med J. 2001 Feb;24(2):114-8.
We report on a 62-year-old woman with nonresectable icteric-type hepatocellular carcinoma who developed obstructive jaundice due to tumor thrombi in the common hepatic duct. External beam radiation therapy with total dose of 38 Gy was given in 10 fractions within 4 weeks. The serum bilirubin level progressively decreased from 30.0 to 1.7 mg/dl with a concomitant reduction of tumor size in the 2 months following radiotherapy. Serum alpha-fetoprotein level decreased from greater than 10,000 to 6540 ng/ml after radiotherapy but increased again due to new growth of tumors. The patient was subsequently treated by transcatheter arterial chemoembolization and was still alive 8 months after the diagnosis of nonresectable icteric-type hepatocellular carcinoma. This result suggests that external beam radiation therapy may be beneficial in some patients with nonresectable icteric-type hepatocellular carcinoma. When combined with other conventional therapies, radiation therapy may play an important role in the treatment of hepatocellular carcinoma.
我们报告了一名62岁患有不可切除黄疸型肝细胞癌的女性患者，其因肝总管肿瘤血栓形成而出现梗阻性黄疸。在4周内分10次给予了总剂量为38 Gy的外照射放疗。放疗后的2个月内，血清胆红素水平从30.0 mg/dl逐渐降至1.7 mg/dl，同时肿瘤大小也有所减小。放疗后血清甲胎蛋白水平从大于10,000 ng/ml降至6540 ng/ml，但由于肿瘤新生长又再次升高。该患者随后接受了经导管动脉化疗栓塞治疗，在诊断为不可切除黄疸型肝细胞癌后8个月仍然存活。这一结果表明，外照射放疗可能对一些不可切除黄疸型肝细胞癌患者有益。当与其他传统疗法联合使用时，放疗可能在肝细胞癌的治疗中发挥重要作用。
