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[一例具有不寻常神经影像学特征的青少年毛细胞型星形细胞瘤]

[A case of juvenile pilocytic astrocytoma with unusual neuroimaging features].

作者信息

Matsushige T, Yoshioka H, Yamasaki F, Sugiyama K, Arita K, Kurisu K, Hamasaki O, Yano T

机构信息

Department of Neurosurgery, Hiroshima University Faculty of Medicine, Japan.

出版信息

No To Shinkei. 2001 Apr;53(4):391-5.

Abstract

We present a case of cerebellar juvenile pilocytic astrocytoma(JPA) with unusual neuroimaging features. The patient was a 14-year-old male who suffered from chronic headaches for a couple of weeks. Plain craniogram showed a decalcification and bulging of the occipital bone. Computed tomography(CT) scans demonstrated low density multiple components with small calcifications in the right cerebellar hemisphere extending to the left. These calcifications were found at the margin of these multi-lobular components. Magnetic resonance imaging(MRI) revealed iso or low intensity on T1 weighted image, and slightly high intensity on T2 weighted image. The lesion indicated more heterogeneous and higher intensity than brain parenchyma on FLAIR imaging, and remarkable higher intensity than brain parenchyma with some small low intensity areas on diffusion weighted imaging. He underwent the complete resection except for the cranial tissue surrounding the pons. Histologic diagnosis was juvenile pilocytic astrocytoma, because of biphasic pattern of bipolar cells and a number of Rosenthal fibers. Generally JPA has sharp and smooth demarcated cysts with well-enhanced mural nodule. It was difficult to diagnose the presented tumor as JPA before operation, since its unusual neuroimaging resembled both dermoid and high grade gliomas.

摘要

我们报告一例具有不寻常神经影像学特征的小脑青少年毛细胞型星形细胞瘤(JPA)。患者为一名14岁男性,有数周的慢性头痛病史。头颅平片显示枕骨脱钙和膨隆。计算机断层扫描(CT)显示右侧小脑半球有低密度多成分区域,并伴有小钙化灶,延伸至左侧。这些钙化位于这些多叶成分的边缘。磁共振成像(MRI)显示在T1加权像上呈等或低信号,在T2加权像上呈稍高信号。在液体衰减反转恢复(FLAIR)成像上,病变显示比脑实质更不均匀且信号更高,在扩散加权成像上比脑实质信号显著更高,并有一些小的低信号区域。除脑桥周围的颅骨组织外,他接受了完整切除。组织学诊断为青少年毛细胞型星形细胞瘤,因为有双相模式的双极细胞和许多罗森塔尔纤维。一般来说,JPA有边界清晰、光滑的囊肿,壁结节强化良好。术前很难将该肿瘤诊断为JPA,因为其不寻常的神经影像学表现类似于皮样囊肿和高级别胶质瘤。

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