Gu J, Li J, Liu S
Department of Anesthesiology, First Affiliated Hospital, Hubei Medical University, Wuhan 430060.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998 Feb;18(2):68-70.
To observe the protective effect of Salvia Miltiorrhizae Composita (SMC) on myocardium injuries induced by oxygen free radicals from ischemic reperfusion in patients undergoing open heart surgery.
Eighteen patients with either congenital ventricular septal defect (VSD) or atrial septal defect (ASD) were divided randomly into control group and treated group, 9 in each. Patients in the treated group were administered intravenously SMC 200 mg/kg before operation and in rewarming period, while patients of the control group received the same volume of balanced salt solution. Serum malonyldialdehyde (MDA), creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) were measured before operation, 30 min after myocardium ischemia, 30 min after reperfusion, 30 min after cardiopulmonary bypass and 24 hours after operation.
Serum MDA, CPK and LDH levels in the treated group at both myocardium ischemic period and ischemic reperfusion period were significantly higher than those at before operation (P < 0.05, P < 0.01). In the treated group, levels of the 3 indexes at myocardium ischemic period increased slightly in comparison with those before operation (P > 0.05), and the levels of them at ischemic reperfusion period were significantly higher than those before operation (P < 0.05), but there was no significant difference between the levels at ischemic reperfusion period and those at 30 min after myocardium ischemia. Comparison between the two groups showed that the serum MDA, CPK and LDH levels were all significantly higher in the control group than those in the control group respectively in all periods (P < 0.01).
SMC could effectively protect myocardium from ischemia and ischemic reperfusion by attenuating the free radical damage and inhibiting lipid peroxidation.
观察复方丹参对心脏直视手术患者缺血再灌注氧自由基所致心肌损伤的保护作用。
将18例先天性室间隔缺损（VSD）或房间隔缺损（ASD）患者随机分为对照组和治疗组，每组9例。治疗组患者于手术前及复温期静脉注射复方丹参200mg/kg，对照组患者给予等量平衡盐溶液。分别于手术前、心肌缺血30分钟、再灌注30分钟、体外循环30分钟及术后24小时测定血清丙二醛（MDA）、肌酸磷酸激酶（CPK）和乳酸脱氢酶（LDH）水平。
治疗组心肌缺血期及缺血再灌注期血清MDA、CPK和LDH水平均显著高于手术前（P<0.05，P<0.01）。治疗组心肌缺血期上述3项指标水平较手术前略有升高（P>0.05），缺血再灌注期水平显著高于手术前（P<0.05），但缺血再灌注期与心肌缺血30分钟时水平比较差异无统计学意义。两组比较，对照组各时段血清MDA、CPK和LDH水平均显著高于治疗组（P<0.01）。
复方丹参可通过减轻自由基损伤、抑制脂质过氧化反应，有效保护心肌免受缺血及缺血再灌注损伤。
