Li C C
Second Affiliated Hospital, Xi-an Medical University.
Zhonghua Wai Ke Za Zhi. 1990 Jan;28(1):16-7, 60-1.
The protective effect of a large dose Vit. C on ischemic myocardium was studied on 10 patients who underwent open heart operation and received 250 mg/kg Vit. C before the start of ECC (Group II). Another 10 similar patients receiving no Vit. C served as a control (Group I). Blood samples were taken from the brachial artery at different time intervals for determination of CPK-MB and MDA in both groups. Considerable increases of serum CPK-MB and MDA in both group I and II were noted. The differences of CPK-MB and MDA concentration between Group I and II were highly significant from 2 to 12 hours postoperatively. The effect of Vit. C in the reduction of the release of CPK-MB and MDA after open heart operation was attributed to its action as an oxygen free radical scavenger, thus decreasing the peroxidation of the lipids present in the cell membrane.
对10例接受心脏直视手术且在体外循环（ECC）开始前接受250mg/kg维生素C的患者（第二组），研究了大剂量维生素C对缺血心肌的保护作用。另外10例相似但未接受维生素C的患者作为对照（第一组）。在不同时间间隔从肱动脉采集血样，以测定两组患者的肌酸磷酸激酶同工酶（CPK-MB）和丙二醛（MDA）。第一组和第二组患者的血清CPK-MB和MDA均显著升高。术后2至12小时，第一组和第二组之间CPK-MB和MDA浓度差异非常显著。心脏直视手术后，维生素C减少CPK-MB和MDA释放的作用归因于其作为氧自由基清除剂的作用，从而减少细胞膜中脂质的过氧化。
