Synthesis of imidazo[1,2-a]pyridine derivatives as antiviral agents.
作者信息
Mavel S, Renou J L, Galtier C, Snoeck R, Andrei G, Balzarini J, De Clercq E, Gueiffier A
机构信息
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Tours, France.
出版信息
Arzneimittelforschung. 2001;51(4):304-9. doi: 10.1055/s-0031-1300042.
PMID:11367871
Abstract
The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies identified hydrophobicity (logP) as the most important factor for activity. From these SAR studies, the antiviral activity could be predicted.
摘要
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