3-Benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents.

作者信息

Chaouni-Enabdallah A, Galtier C, Allouchi H, Kherbeche A, Chavignon O, Teulade J C, Witvrouw M, Pannecouque C, Snoeck R, Andrei G, Balzarini J, De Clercq E, Fauvelle F, Enguehard C, Gueiffier A

机构信息

EA Groupe de Recherche en Chimie Hétérocyclique et Thérapeutique, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Tours, France.

出版信息

Chem Pharm Bull (Tokyo). 2001 Dec;49(12):1631-5. doi: 10.1248/cpb.49.1631.

DOI:10.1248/cpb.49.1631

PMID:11767086

Abstract

This work reports the synthesis and the antiviral activities of 3-benzamido, 3-phenylureido and 3-phenylthioureido derivatives in the imidazo[1,2-a]pyridine series. The structure was proven by NMR spectroscopy. The synthesized compounds were evaluated against a large number of viruses. The 3-phenylthioureido derivative 7 showed moderate activity against human cytomegalovirus (HCMV) in vitro. The crystallographic data for 8 are also reported and explain the absence of activity against human immunodeficiency virus (HIV).

摘要