Puerstinger Gerhard, Paeshuyse Jan, De Clercq Erik, Neyts Johan
Institut für Pharmazie, Abteilung Pharmazeutische Chemie, Universität Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria.
Bioorg Med Chem Lett. 2007 Jan 15;17(2):390-3. doi: 10.1016/j.bmcl.2006.10.039. Epub 2006 Oct 19.
A novel class of inhibitors of the hepatitis C virus [substituted 2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridines] is described. Introduction of a fluorine in position 2 of the 2-phenyl substituent of the lead anti-pestivirus compound 1 (5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine) resulted in an analogue with selective activity against HCV in the subgenomic replicon system.
描述了一类新型的丙型肝炎病毒抑制剂[取代的2-(2-氟苯基)-5H-咪唑并[4,5-c]吡啶]。在先导抗瘟病毒化合物1（5-[(4-溴苯基)甲基]-2-苯基-5H-咪唑并[4,5-c]吡啶）的2-苯基取代基的2位引入氟，得到了在亚基因组复制子系统中对HCV具有选择性活性的类似物。
