Whitby E, Paley M N, Davies N, Sprigg A, Griffiths P D
University of Sheffield, Section of Academic Radiology, Royal Hallamshire Hospital, UK.
BJOG. 2001 May;108(5):519-26. doi: 10.1111/j.1471-0528.2001.00115.x.
To assess the ability of ultrafast magnetic resonance imaging to visualise abnormalities in the central nervous system of third trimester fetuses in utero and to compare the results with the current 'reference standard' of ultrasound and postnatal imaging or post-mortem data.
A prospective, observational study comparing the diagnostic accuracy of two imaging methods: antenatal ultrasound and antenatal magnetic resonance with each other and postnatal or post mortem data.
Twenty-one pregnant women of 19-36 weeks of gestation whose fetus were thought to have a central nervous system abnormality on the basis of antenatal ultrasound. The women had either not been offered or had refused a termination and were willing to have a magnetic resonance scan.
A 1.5T magnetic resonance scanner used a single shot fast spin echo sequence, in three image planes. The results were compared with the ultrasound results obtained by an experienced investigator independently. A series of 21 patients, with a range of pathologies of central nervous system, were imaged. Postnatal ultrasound and/or magnetic resonance imaging, or post-mortem data were used for additional confirmation of the pathology in all cases.
The magnetic resonance report was different to the ultrasound in 10/21 (47.6%), magnetic resonance provided information additional to the ultrasound in 5/21 (23.8%), ultrasound and magnetic resonance results agreed in 6/21 cases (28.6%).
Magnetic resonance in the third trimester provides a useful adjuvant to ultrasound imaging of the fetus when assessing abnormalities of the central nervous system after 19 weeks of gestation particularly if the abnormality involves the posterior fossa.
评估超快磁共振成像对子宫内孕晚期胎儿中枢神经系统异常的可视化能力，并将结果与当前超声及产后成像或尸检数据的“参考标准”进行比较。
一项前瞻性观察性研究，比较两种成像方法（产前超声和产前磁共振成像）相互之间以及与产后或尸检数据的诊断准确性。
21名孕周为19 - 36周的孕妇，其胎儿基于产前超声被认为有中枢神经系统异常。这些孕妇要么未被提供终止妊娠的选择，要么拒绝终止妊娠，且愿意接受磁共振扫描。
使用1.5T磁共振扫描仪，采用单次激发快速自旋回波序列，在三个成像平面进行扫描。结果与由一名经验丰富的研究者独立获得的超声结果进行比较。对一系列21例患有各种中枢神经系统病变的患者进行成像。所有病例均使用产后超声和/或磁共振成像，或尸检数据对病变进行进一步确认。
磁共振报告与超声报告不同的有10/21（47.6%），磁共振提供了超声之外额外信息的有5/21（23.8%），超声和磁共振结果一致的有6/21例（28.6%）。
孕晚期磁共振成像在评估妊娠19周后胎儿中枢神经系统异常时，尤其是异常涉及后颅窝时，是超声成像的一种有用辅助手段。
