Johansson M, Wentz E, Fernell E, Strömland K, Miller M T, Gillberg C
Department of Child and Adolescent Psychiatry, Göteborg University, Sweden.
Dev Med Child Neurol. 2001 May;43(5):338-45. doi: 10.1017/s0012162201000627.
The prevalence of autistic disorder was analysed in 25 individuals with Möbius sequence, a disorder with brain-stem dysfunction. The sample consisted of 18 males and seven females (20 participants were aged 2 to 22 years, and five were aged 1, 19 and 23 months, and 55 years old). Participants were recruited after a nationwide call and were part of a multidisciplinary study of individuals with Möbius sequence. They were given a meticulous neuropsychiatric examination including standardized autism diagnostic interviews. Ten individuals had an autistic spectrum disorder. Six of these met all diagnostic criteria for autism. In 23 individuals cognitive development could be assessed. Eight of those 23 patients had clear learning disability and six individuals were functioning in the normal but subaverage range. Autistic spectrum disorder and learning disability occurred in more than a third of the examined patients. Considering the hospital-based nature of the sample, these findings may be overestimates. Nevertheless, awareness of this coexistence is important in the diagnosis and habilitation care of children with Möbius sequence. Moreover, the results provide further support for the notion of a subgroup of autistic spectrum disorders being caused by first trimester brain-stem damage.
对25例患有莫比乌斯序列（一种脑干功能障碍疾病）的个体进行了自闭症谱系障碍患病率分析。样本包括18名男性和7名女性（20名参与者年龄在2至22岁之间，5名年龄分别为1岁、19个月、23个月和55岁）。参与者是在全国范围内招募的，是莫比乌斯序列个体多学科研究的一部分。他们接受了细致的神经精神检查，包括标准化的自闭症诊断访谈。10名个体患有自闭症谱系障碍。其中6名符合自闭症的所有诊断标准。在23名个体中可以评估认知发展。这23名患者中有8名有明显的学习障碍，6名个体功能处于正常但低于平均水平的范围。超过三分之一的受检患者出现自闭症谱系障碍和学习障碍。考虑到样本基于医院的性质，这些发现可能存在高估。尽管如此，认识到这种共存情况对于莫比乌斯序列患儿的诊断和康复护理很重要。此外，研究结果为自闭症谱系障碍的一个亚组由孕早期脑干损伤引起这一观点提供了进一步支持。
