Arnman K, Carlström S, Thorell J I
Acta Med Scand. 1975 Apr;197(4):271-4. doi: 10.1111/j.0954-6820.1975.tb04916.x.
The plasma concentrations of free fatty acids (FFA), glycerol and insulin as well as the blood glucose concentration have been followed in two groups of subjects after infusions of theophyllamine. Each individual was examined twice. The 5 subjects in group 2 were given an infusion of norepinephrine before the theophyllamine at one of the examinations and saline at the other. The 6 subjects in group II were given an infusion of norephinephrine at both examinations, followed by theophyllamine on one occasion and by saline on the other. Thus, the subjects in both groups served as their own controls. It was found that theophyllamine caused lipid mobilization, as measured by the plasma FFA and plasma glycerol concentrations, both when given as the only active drug and when given after norepinephrine. The blood glucose concentration rose slightly after norepinephrine and the plasma insulin level increased concomittantly. When theophylline was given as the only active drug, there was no increase in the blood glucose but the plasma insulin concentration rose slightly.
在两组受试者输注氨茶碱后，对其游离脂肪酸（FFA）、甘油和胰岛素的血浆浓度以及血糖浓度进行了跟踪监测。每位受试者均接受了两次检查。在其中一次检查中，第2组的5名受试者在输注氨茶碱之前先输注去甲肾上腺素，另一次检查则输注生理盐水。第II组的6名受试者在两次检查中均输注去甲肾上腺素，然后在一次检查中接着输注氨茶碱，另一次检查则输注生理盐水。因此，两组受试者均作为自身对照。结果发现，无论是单独作为活性药物给药，还是在去甲肾上腺素之后给药，通过血浆FFA和血浆甘油浓度测定，氨茶碱都会引起脂质动员。去甲肾上腺素给药后血糖浓度略有升高，同时血浆胰岛素水平也随之增加。当氨茶碱单独作为活性药物给药时，血糖没有升高，但血浆胰岛素浓度略有上升。
