Godard P, Chaintreuil J, Bensadoun J, Parelon G, de Paulet A C, Michel F B
Thorax. 1984 Feb;39(2):137-9. doi: 10.1136/thx.39.2.137.
As theophylline is known to stimulate lipolysis and lipid mobilisation, plasma concentrations of malonyl dialdehyde were studied in asthmatic patients being treated with sustained release theophylline. Malonyl dialdehyde was assessed as malonyl dialdehyde like material (MDA-LM) by the thiobarbituric acid assay. In a kinetic study (eight patients) plasma MDA-LM concentrations were found to be significantly higher after 30 than after eight days' treatment or before treatment, but not significantly different after 90 than after 30 days. In a comparative study (29 patients and 29 healthy volunteers) the mean plasma MDA-LM concentration was shown to be very significantly higher in the asthmatic group. The results are probably explained by an effect of theophylline on lipid peroxidation, and the effect of long term treatment on plasma MDA-LM merits further investigation.
由于已知茶碱可刺激脂肪分解和脂质动员，因此对接受缓释茶碱治疗的哮喘患者的丙二醛血浆浓度进行了研究。通过硫代巴比妥酸测定法将丙二醛评估为丙二醛样物质（MDA-LM）。在一项动力学研究（8名患者）中，发现治疗30天后血浆MDA-LM浓度显著高于治疗8天后或治疗前，但90天后与30天后无显著差异。在一项对照研究（29名患者和29名健康志愿者）中，哮喘组的平均血浆MDA-LM浓度显示非常显著地更高。结果可能是由茶碱对脂质过氧化的作用所解释，长期治疗对血浆MDA-LM的影响值得进一步研究。
