重链铁蛋白的抑制增加了人K562细胞的不稳定铁池。
Repression of the heavy ferritin chain increases the labile iron pool of human K562 cells.
作者信息
Kakhlon O, Gruenbaum Y, Cabantchik Z I
机构信息
Department of Biological Chemistry, Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel.
出版信息
Biochem J. 2001 Jun 1;356(Pt 2):311-6. doi: 10.1042/0264-6021:3560311.
Abstract
The role of ferritin in the modulation of the labile iron pool was examined by repressing the heavy subunit of ferritin in K562 cells transfected with an antisense construct. Repression of the heavy ferritin subunit evoked an increase in the chemical levels and pro-oxidant activity of the labile iron pool and, in turn, caused a reduced expression of transferrin receptors and increased expression of the light ferritin subunit.
摘要
通过在转染反义构建体的K562细胞中抑制铁蛋白重亚基，研究了铁蛋白在调节不稳定铁池中的作用。铁蛋白重亚基的抑制导致不稳定铁池的化学水平和促氧化活性增加，进而导致转铁蛋白受体表达降低和轻链铁蛋白亚基表达增加。
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