Carbonell J L, Rodriguez J, Aragón S, Velazco A, Tanda R, Sánchez C, Barambio S, Chami S, Valero F
Clinic "Mediterrania Medica," Valencia, Castelló, Spain.
Contraception. 2001 Mar;63(3):131-6. doi: 10.1016/s0010-7824(01)00189-5.
The objective of this study was to evaluate the safety and efficacy of 1000 microg misoprostol vaginally (Cytotec) self-administered into the vagina for medical abortion. Three-hundred women with gestations between 42 and 63 days, with previous written consent, received vaginal misoprostol every 24 h up to a maximum of three doses for abortion. Outcome measures assessed included: successful abortion (complete abortion without surgery), side effects, decrease in hemoglobin, mean time of vaginal bleeding, mean expulsion time and mean time of returning of menses. Complete abortion occurred in 279/300 (93.0%, 95% CI 90, 96) patients. Medication to relieve symptoms was administered to all subjects after every misoprostol dose. Vaginal bleeding lasted 14.7 +/- 5.4 days. Mean expulsion time was 8.1 +/- 3.0 h for those who aborted after the first misoprostol dose. The mean drop in hemoglobin was statistically significant (p = 0.0001) but without clinical relevance. The frequencies of nausea and diarrhea were high. According to the observed outcomes, 1000-microg misoprostol vaginally could be a valid method to terminate pregnancies up to nine weeks gestation.
本研究的目的是评估将1000微克米索前列醇（喜克溃）经阴道自行给药用于药物流产的安全性和有效性。300名妊娠42至63天且已签署书面知情同意书的妇女，每24小时经阴道给予米索前列醇，最多使用三剂进行流产。评估的结局指标包括：流产成功（无需手术的完全流产）、副作用、血红蛋白下降情况、阴道出血平均时间、平均排出时间和月经恢复平均时间。279/300（93.0%，95%可信区间90, 96）例患者发生完全流产。每次给予米索前列醇后，对所有受试者均给予缓解症状的药物。阴道出血持续14.7±5.4天。首次给予米索前列醇后流产的患者平均排出时间为8.1±3.0小时。血红蛋白平均下降具有统计学意义（p = 0.0001），但无临床相关性。恶心和腹泻的发生率较高。根据观察到的结果，经阴道给予1000微克米索前列醇可能是终止妊娠9周内妊娠的有效方法。
