Salakos N, Kountouris A, Botsis D, Rizos D, Gregoriou O, Detsis G, Creatsas G
2nd Department of Obstetrics and Gynaecology, University of Athens, Aretaieion Hospital, Greece.
Eur J Contracept Reprod Health Care. 2005 Dec;10(4):249-54. doi: 10.1080/13625180500178676.
The objective of the study was to evaluate the efficacy and safety of 800 microg of misoprostol every 12 h, for a period of 36 h for pharmacological abortion. A group of 162 volunteer women with gestations between 50 and 63 days received misoprostol every 12 h up to a maximum of three doses for abortion. Outcome measures assessed included: successful abortion (complete abortion without requiring surgery), side effects, and a decrease in hemoglobin, mean time of vaginal bleeding, mean expulsion time and mean time of returning of menses. Complete abortion occurred in 148 of 162 (91%, 95% confidence interval 87.95) patients. The mean decrease in hemoglobin was statistically significant (p = 0.001). Vaginal bleeding lasted 8.0 +/- 3.2 days, spotting 8.0 +/- 3.5 days, and total bleeding 16 +/- 4.0 days. The mean expulsion time was 8.5 +/- 4.0 h. According to the observed outcomes, 800 microg of misoprostol vaginally could be a valid method to terminate pregnancies up to 9 weeks of gestation.
本研究的目的是评估每12小时服用800微克米索前列醇、持续36小时用于药物流产的有效性和安全性。一组162名妊娠50至63天的志愿女性每12小时服用米索前列醇，最多服用三剂以终止妊娠。评估的结果指标包括：流产成功（无需手术的完全流产）、副作用、血红蛋白下降情况、阴道出血平均时间、平均排出时间和月经恢复平均时间。162名患者中有148名（91%，95%置信区间87.95）发生了完全流产。血红蛋白的平均下降具有统计学意义（p = 0.001）。阴道出血持续8.0 +/- 3.2天，点滴出血8.0 +/- 3.5天，总出血时间16 +/- 4.0天。平均排出时间为8.5 +/- 4.0小时。根据观察结果，阴道给予800微克米索前列醇可能是终止妊娠9周以内的有效方法。
