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线粒体内重组——这就是为什么一些线粒体基因四处游走的原因吗?

Intramitochondrial recombination - is it why some mitochondrial genes sleep around?

作者信息

Dowton M, Campbell N J.H.

出版信息

Trends Ecol Evol. 2001 Jun 1;16(6):269-271. doi: 10.1016/s0169-5347(01)02182-6.

DOI:10.1016/s0169-5347(01)02182-6
PMID:11369092
Abstract

A new paper by Kajander et al. undermines the general view that mitochondria do not recombine. The authors discovered the existence of 'sublimons', rearranged mitochondrial genomes present at very low levels in healthy human patients. Crucially, the different rearranged mitochondrial genomes can theoretically be interconverted through intramitochondrial recombination. The putative operation of intramitochondrial recombination should impact on our ideas of how mitochondrial genes evolve, particularly with respect to how mitochondrial genomes rearrange.

摘要

卡扬德等人的一篇新论文对线粒体不会重组的普遍观点提出了质疑。作者发现了“亚线粒体基因组”的存在,即在健康人类患者中以极低水平存在的重排线粒体基因组。至关重要的是,理论上不同的重排线粒体基因组可以通过线粒体内重组相互转化。线粒体内重组的假定作用应该会影响我们对线粒体基因如何进化的看法,特别是关于线粒体基因组如何重排的看法。

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