Thomason P R, Matzke H A
Am J Phys Med. 1975 Jun;54(3):113-31.
The effects of ischemia, induced by a tourniquet, were investigated on 36 adult Holtzman female rates in terms of damage to the ventral horn cell of the spinal cord and tibial nerve and motor end-plate degeneration and regeneration. Clinically, the rats were tested for sensory and motor loss and recovery and these results were compared with the histological findings. Ischemic periods of 2, 4, 6, and 8 hours were used followed by survival times of 3 weeks to 9 months. Histologically, there was degeneration and regeneration found to varying degrees in the nerve and motor end-plate. There were no changes found in the ventral horn cell. There was a loss of pain sensation in all animals, except the 2 hour group, and a loss of motor function. Motor function, preceded by sensation, returned in all animals. With the absence of ventral horn cell damage it was not surprising to find adequate regeneration histologically and, therefore, a return of both sensory and motor function.
研究了止血带诱导的缺血对36只成年雌性霍尔茨曼大鼠脊髓腹角细胞、胫神经以及运动终板损伤和再生的影响。临床上，对大鼠进行感觉和运动丧失及恢复情况的测试，并将这些结果与组织学发现进行比较。采用了2小时、4小时、6小时和8小时的缺血期，随后的存活时间为3周至9个月。组织学上，神经和运动终板出现了不同程度的变性和再生。腹角细胞未发现变化。除2小时组外，所有动物均出现痛觉丧失和运动功能丧失。所有动物的运动功能在感觉恢复之后恢复。由于腹角细胞未受损，因此在组织学上发现有充分的再生以及感觉和运动功能的恢复也就不足为奇了。
