Schneider A, Dürst M, Kaufmann A M
Abteilung Frauenheilkunde der Friedrich-Schiller-Universität Jena.
Zentralbl Gynakol. 2001 Apr;123(4):179-85. doi: 10.1055/s-2001-14774.
Certain molecularly defined types of human papillomaviruses (HPV) induce, by interaction with additional cofactors, cervical cancer. In comparison to infection with HPV, all risk factors identified to date are less important. In addition to HPV a not yet classified genetic predisposition is important. Identification of HPV in cervical smears is done by detection of viral DNA. PCR based methods have the highest specificity. Currently, first vaccination studies with therapeutic vaccines are performed and phase I/II trials for prophylactic vaccination show promising results.
某些分子定义类型的人乳头瘤病毒（HPV）通过与其他辅助因子相互作用诱发宫颈癌。与HPV感染相比，迄今确定的所有风险因素都不那么重要。除HPV外，一种尚未分类的遗传易感性也很重要。通过检测病毒DNA在宫颈涂片检查中鉴定HPV。基于PCR的方法具有最高的特异性。目前，正在进行治疗性疫苗的首次疫苗接种研究，预防性疫苗接种的I/II期试验显示出有希望的结果。
