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Advanced glycation: an important pathological event in diabetic and age related ocular disease.

作者信息

Stitt A W

机构信息

Department of Ophthalmology, The Queen's University of Belfast, The Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UK

出版信息

Br J Ophthalmol. 2001 Jun;85(6):746-53. doi: 10.1136/bjo.85.6.746.

Abstract
摘要

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Advanced glycation end products induce blood-retinal barrier dysfunction in normoglycemic rats.
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AGEs induce oxidative stress and activate protein kinase C-beta(II) in neonatal mesangial cells.
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Structural macromolecules and supramolecular organisation of the vitreous gel.
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Maillard reactions in lens proteins: methylglyoxal-mediated modifications in the rat lens.
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An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness.
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