Hu D J, Vanichseni S, Mastro T D, Raktham S, Young N L, Mock P A, Subbarao S, Parekh B S, Srisuwanvilai L, Sutthent R, Wasi C, Heneine W, Choopanya K
Division of HIV/AIDS Prevention--Surveillance and Epidemiology, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia 30333, USA.
AIDS. 2001 Apr 13;15(6):683-91. doi: 10.1097/00002030-200104130-00003.
Information on early HIV-1 infection has come primarily from studies of persons infected with subtype B in North America and Europe; much less is known about other subtypes. The purpose of the present study was to compare the virologic and immunologic parameters following seroconversion among recently-infected persons infected with either of two different HIV-1 subtypes.
A prospective cohort study was carried out at methadone treatment clinics administered by the Bangkok Metropolitan Administration, Thailand. A total of 130 HIV-1-infected seroconverters (103 with HIV-1 subtype E and 27 with subtype B) were included in the study. The main outcome measures were serial HIV-1 RNA viral load, natural killer cell percentage, CD4 and CD8 lymphocyte counts since seroconversion.
The demographic and behavioral characteristics of persons with either subtype were similar. Median RNA viral levels at the earliest time within 3 months of seroconversion were more than three times higher for persons infected with subtype E than subtype B (63 100 versus 18 050 copies/ml, P = 0.001). However, this difference decreased over time such that viral loads were similar at 12, 18, and 24 months following seroconversion. The CD4 and CD8 lymphocyte counts were similar in infections with either subtype during the entire period up to 24 months post-seroconversion.
Higher viral loads associated with subtype E may result from inter-subtype biological differences; however, the epidemiological dynamics of transmission in Bangkok may have also contributed to this phenomenon.
关于早期HIV-1感染的信息主要来自北美和欧洲对B亚型感染者的研究；而对于其他亚型的了解则少得多。本研究的目的是比较两种不同HIV-1亚型感染者血清转化后的病毒学和免疫学参数。
在泰国曼谷市政府管理的美沙酮治疗诊所开展了一项前瞻性队列研究。共有130名HIV-1感染血清转化者（103名感染HIV-1 E亚型，27名感染B亚型）纳入本研究。主要观察指标为血清转化后的HIV-1 RNA病毒载量系列、自然杀伤细胞百分比、CD4和CD8淋巴细胞计数。
两种亚型感染者的人口统计学和行为特征相似。血清转化后3个月内最早时间点，E亚型感染者的RNA病毒水平中位数比B亚型感染者高出三倍多（分别为63100拷贝/毫升和18050拷贝/毫升，P = 0.001）。然而，这种差异随时间减小，以至于血清转化后12、18和24个月时病毒载量相似。血清转化后长达24个月的整个期间，两种亚型感染中的CD4和CD8淋巴细胞计数相似。
与E亚型相关的较高病毒载量可能源于亚型间的生物学差异；然而，曼谷的传播流行病学动态也可能导致了这一现象。
