斑马鱼E-钙黏蛋白：早期胚胎发育过程中的表达及大脑发育过程中的调控
Zebrafish E-cadherin: expression during early embryogenesis and regulation during brain development.
作者信息
Babb S G, Barnett J, Doedens A L, Cobb N, Liu Q, Sorkin B C, Yelick P C, Raymond P A, Marrs J A
机构信息
Department of Medicine, Indiana University Medical Center, 1220 South Drive, Indianapolis, IN 46202-5116, USA.
出版信息
Dev Dyn. 2001 Jun;221(2):231-7. doi: 10.1002/dvdy.1132.
Zebrafish E-cadherin (cdh1) cell adhesion molecule cDNAs were cloned. We investigated spatial and temporal expression of cdh1 during early embryogenesis. Expression was observed in blastomeres, the anterior mesoderm during gastrulation, and developing epithelial structures. In the developing nervous system, cdh1 was detected at the pharyngula stage (24 hpf) in the midbrain-hindbrain boundary (MHB). Developmental regulation of MHB formation involves wnt1 and pax2.1. wnt1 expression preceded cdh1 expression during MHB formation, and cdh1 expression in the MHB was dependent on normal development of this structure.
斑马鱼E-钙黏蛋白（cdh1）细胞黏附分子的cDNA被克隆出来。我们研究了cdh1在早期胚胎发育过程中的时空表达。在卵裂球、原肠胚形成期的前中胚层以及发育中的上皮结构中观察到了表达。在发育中的神经系统中，在咽期（受精后24小时）的中脑-后脑边界（MHB）检测到了cdh1。MHB形成的发育调控涉及wnt1和pax2.1。在MHB形成过程中，wnt1的表达先于cdh1的表达，并且MHB中cdh1的表达依赖于该结构的正常发育。
Zotero 插件