Holloway E L, Polumbo R A, Harrison D C
Br Heart J. 1975 May;37(5):482-5. doi: 10.1136/hrt.37.5.482.
Twenty-one patients, 11 with normal pulomonary artery pressures and 10 with pulmonary hypertension, had haemodynamic measurements performed before and during dopamine infusion while undergoing cardiac catheterization, in order to evaluate the circulatory effects of dopamine in pulmonary hypertension. In both groups on average, heart rate, pulmonary artery mean pressure, aortic mean pressure, and cardiac index increased significantly, while systemic vascular resistance fell significantly during dopamine administration. In neither group did the average pulmonary vascular resistance or right ventricular end-diastolic pressure change significantly. We conclude that dopamine is a safe and potentially useful drug for the treatment of reduced cardiac output, even in patients with pulmonary hypertension.
21例患者，其中11例肺动脉压力正常，10例患有肺动脉高压，在进行心导管检查时，于多巴胺输注前及输注期间进行了血流动力学测量，以评估多巴胺对肺动脉高压患者循环系统的影响。两组患者平均而言，在多巴胺给药期间，心率、肺动脉平均压、主动脉平均压和心脏指数均显著升高，而体循环血管阻力显著下降。两组患者的平均肺血管阻力或右心室舒张末期压力均无显著变化。我们得出结论，即使对于肺动脉高压患者，多巴胺也是一种安全且可能有用的治疗心输出量降低的药物。
