Kundu Aman, Singh Gyanesh
Fs Convent School, Jind, Hariyana, 126113, India.
School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
F1000Res. 2018 Mar 1;7:254. doi: 10.12688/f1000research.12180.1. eCollection 2018.
Dopamine is a key neurotransmitter, and is widely used as a central nervous system (CNS) agent. Dopamine plays an important role in humans, including a major role in reward and motivation behaviour. Several addictive drugs are well known to increase neuronal dopamine activity. We selected , an important model organism, to investigate the effect(s) of selected CNS agents on heart rate. Dopamine's effects on 's heart has not been previously reported. Caffeine is a well-known and widely consumed stimulant. Ethanol is well known for its effects on both neurological and physiological processes in mammals. We tested the effect of dopamine on the heart rate of , and compared its effect with caffeine and ethanol alone and in combination. Both caffeine and dopamine were found to instantly increase the heart rate of in a dose-dependent manner. Interestingly, caffeine synergized with dopamine to increase 's heart rate. As ethanol decreased the heart rate of and dopamine increased the heart rate of we wanted to test the effect of these molecules in combination Indeed, Dopamine was able to restore the ethanol-induced decrease in the heart rate of . Effects of these CNS agents on can possibly be correlated with similar effects in the case of mammals.
多巴胺是一种关键的神经递质，被广泛用作中枢神经系统（CNS）药物。多巴胺在人类中发挥着重要作用，包括在奖赏和动机行为中起主要作用。众所周知，几种成瘾性药物会增加神经元多巴胺活性。我们选择了一种重要的模式生物来研究选定的中枢神经系统药物对心率的影响。多巴胺对该模式生物心脏的影响此前尚未见报道。咖啡因是一种广为人知且广泛消费的兴奋剂。乙醇因其对哺乳动物神经和生理过程的影响而闻名。我们测试了多巴胺对该模式生物心率的影响，并将其单独以及与咖啡因和乙醇联合使用时的效果进行了比较。结果发现，咖啡因和多巴胺均能以剂量依赖的方式立即增加该模式生物的心率。有趣的是，咖啡因与多巴胺协同作用可增加该模式生物的心率。由于乙醇会降低该模式生物的心率，而多巴胺会增加其心率，我们想要测试这两种分子联合使用时的效果。事实上，多巴胺能够恢复乙醇引起的该模式生物心率下降。这些中枢神经系统药物对该模式生物的影响可能与在哺乳动物中的类似影响相关。
