Park K, Kang H K, Seo J J, Kim H J, Ryu S B, Jeong G W
Department of Urology, Chonnam National University Medical School, Kwangju, South Korea.
Urology. 2001 Jun;57(6):1189-94. doi: 10.1016/s0090-4295(01)00992-x.
To evaluate, for the first time, the cerebral regions associated with female sexual arousal evoked by visual stimulation using noninvasive blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI).
A total of 6 healthy right-handed female volunteers (mean age 33 years, range 25 to 41) underwent fMRI on a 1.5-T MR scanner, in which the BOLD technique was used to create fMR images reflecting local brain activities. Real-time visual stimulation was performed with alternatively combined erotic and nonerotic films to identify the activated brain regions associated with sexual response. The perceived sexual arousal response was assessed using a scale ranging from 1 (no change) to 5 (maximal increase).
The mean score for perceived sexual arousal by erotic visual stimulation was 2.7 on the 5-point scale and was unchanged by nonerotic stimulation. During the visual task, the occipital cortex was activated by both the erotic and the nonerotic films; however, the following cerebral areas were significantly (P <0.05) activated, varying from 4 of 6 to 6 of 6 women: inferior frontal lobe, cingulate gyrus, insula gyrus, corpus callosum, thalamus, caudate nucleus, globus pallidus, and inferior temporal lobe.
This study is the first to evaluate noninvasive BOLD-fMRI in identifying cerebral regions associated with sexual arousal response evoked by visual stimulation in women.
首次使用无创性血氧水平依赖性功能磁共振成像（BOLD-fMRI）评估与视觉刺激诱发的女性性唤起相关的脑区。
共有6名健康右利手女性志愿者（平均年龄33岁，范围25至41岁）在1.5-T磁共振扫描仪上接受功能磁共振成像检查，采用BOLD技术生成反映局部脑活动的功能磁共振图像。通过交替播放色情和非色情影片进行实时视觉刺激，以识别与性反应相关的激活脑区。使用从1（无变化）到5（最大增加）的量表评估感知到的性唤起反应。
在5分量表上，色情视觉刺激引起的性唤起平均得分为2.7，非色情刺激未使其改变。在视觉任务期间，枕叶皮层在色情和非色情影片刺激下均被激活；然而，以下脑区有显著激活（P <0.05），6名女性中有4至6名出现这种情况：额下回、扣带回、脑岛、胼胝体、丘脑、尾状核、苍白球和颞下回。
本研究首次评估了无创性BOLD-fMRI在识别与女性视觉刺激诱发的性唤起反应相关脑区方面的作用。
